论文部分内容阅读
本文主要观察硫酸铝钾——饮用水净化剂引致小鼠肝酶组化,超微结构和组织结构的变化。动物30只,分为正常组、硫酸铝钾大、小剂量组。实验结果:硫酸铝钾10mg/kg/日(大剂量组)与5mg/kg/日(小剂量组)动物用药10天、80天均可使肝SDH酶活性降低;肝细胞线粒体肿胀、嵴断裂和溶解。在光学显微镜下用药80天后大部分肝细胞肿胀,胞浆疏松淡染、肝小叶内可见呈小灶状分布的炎性细胞浸润,主要为淋巴细胞及浆细胞,门管区偶见少许炎性细胞,但肝小叶和门管区未见结缔组织增生。为此,硫酸铝钾作为净水剂,不宜用量过大。
In this paper, the main observation aluminum potassium sulfate - drinking water purification agent induced liver enzymes, ultrastructural and organizational changes. 30 animals were divided into normal group, aluminum potassium sulfate large and small dose group. The results showed that SDH activity of hepatic stellate cells could be reduced by 10 mg / kg / day (high dose group) and 5 mg / kg / day (low dose group) And dissolve. Most of the hepatocytes were swollen and the cytoplasm was loosely stained after 80 days under the optical microscope. Inflammatory cells infiltrated into the small lobules in the hepatic lobules were found mainly in lymphocytes and plasma cells. Occasionally, a few inflammatory cells were found in the portal area, However, there was no connective tissue hyperplasia in hepatic lobules and portal area. To this end, aluminum potassium sulfate as water purification agent, should not be excessive.