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目的探讨米索前列腺舌下含服与阴道给药对停经49 d以上早孕药物流产效果的影响。方法所有患者依照米索前列醇给药途径,分为组Ⅰ(舌下含服,268例)和组Ⅱ(阴道给药,268例),比较完全流产率、流产耗时、阴道流血量等指标。结果所有患者中完全流产者共计385例,完全流产率组Ⅰ为75.00%(201/268),组Ⅱ为87.69%(235/268),两组间完全流产率比较差异有统计学意义(χ~2=14.185,P<0.01)。完全流产药流耗时两组间比较差异有统计学意义(t=12.197,P<0.01)。两组阴道流血量分别为(65.3±27.3)ml和(65.1±27.8)ml,差异未见统计学意义。结论米索前列醇舌下含服的完全流产率高,给药便捷,不明显增加阴道流血量,是一种较好的给药方式。
Objective To investigate the effect of misoprostol sublingual and vaginal administration on abortion after 49 days of pregnancy. Methods All patients were divided into group Ⅰ (sublingual administration, 268 cases) and group Ⅱ (vaginal administration, 268 cases) according to the route of misoprostol administration. The complete abortion rate, abortion time and vaginal bleeding volume index. Results A total of 385 cases of complete abortion were found in all patients. The rate of complete abortion was 75.00% (201/268) in group Ⅰ, and 87.69% (235/268) in group Ⅱ, the difference was statistically significant between two groups (χ ~ 2 = 14.185, P <0.01). Complete abortion drug flow when the two groups was statistically significant difference (t = 12.197, P <0.01). The amount of vaginal bleeding in the two groups was (65.3 ± 27.3) ml and (65.1 ± 27.8) ml, respectively, with no significant difference. Conclusion Misoprostol sublingual delivery rate of complete abortion, convenient administration, does not significantly increase vaginal bleeding, is a better way of administration.