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近年来,有愈来愈多的证据揭示,除了T、B淋巴细胞参与骨髓移植(BMT)中的免疫反应以外,自然杀伤(NK)细胞也起着重要的作用。有关NK细胞参与造血调控、移植排斥反应和移植物抗宿主病(GVHD)方面,国外已有不少文献报道,它在BMT中的作用正引起各国学者的重视,本文就这些方面作一概述。一、参与造血调控自Nunn等1977年发现小鼠NK细胞对骨髓细胞(BMC)有杀伤作用,以及Morris等发现人NK细胞能抑制体外培养中正常的BMC生长以后,广泛研究了NK细胞对人、小鼠和狗等的造血细胞的生长抑制与杀伤作用。根据实验结果,Cudkowicz和Kiessling等首先提出了NK细胞参
In recent years, there is growing evidence that natural killer (NK) cells play an important role in addition to the involvement of T lymphocytes in the immune response in bone marrow transplantation (BMT). Concerning the involvement of NK cells in hematopoietic regulation, transplant rejection and graft-versus-host disease (GVHD), there are many foreign reports that its role in BMT is arousing the attention of scholars all over the world. This article gives an overview of these aspects. First, participate in the regulation of hematopoiesis Nunn et al. (1977) found that murine NK cells have a killing effect on bone marrow cells (BMC), and Morris found that human NK cells can inhibit normal BMC growth in vitro after extensive study of NK cells on human , Mouse and dog hematopoietic cells growth inhibition and killing effect. According to the experimental results, Cudkowicz and Kiessling first proposed NK cell parameters