目的探讨青春期起病的系统性红斑狼疮(SLE)患者的病情特点。方法对98例青春期起病的SLE患者和372例成人SLE患者的临床特点进行了比较。观察指标包括疾病累及的器官数目、SLE疾病活动指数(SLEDAI)积分、病情的转归和病死率等。结果青春期起病的SLE患者占全部SLE患者的20．85%。青春期起病的患者比成人患者疾病累及的器官数目多、SLEDAI积分高、难治性SLE多、病死率高。结论青春期起病的SLE患者并非少见,这一部分患者病情变化快、病死率高,应予以高度重视。 Objective To investigate the disease characteristics of patients with adolescent onset systemic lupus erythematosus (SLE). Methods The clinical features of 98 adolescent SLE patients and 372 adult SLE patients were compared. Observational indicators include the number of organs involved in the disease, SLE disease activity index (SLEDAI) points, the prognosis of the disease and mortality. Results The onset of SLE in adolescents accounted for 20.85% of all SLE patients. Adolescent onset disease than adult patients involved in the number of organs, high SLEDAI score, refractory SLE more, high mortality. Conclusion The onset of SLE in adolescence is not uncommon, this part of the patient’s condition changes rapidly, high mortality, should be highly valued.