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《不合理用药分析200例》(下简称“200例”)的第7例的处方为: 氨苄青霉素注射剂2.0 维生素C注射液3.0 10%葡萄糖注射液1000ml/ 作者分析:氨苄青霉素与维生素C在10%葡萄糖输液中混和,由于pH降低而使青霉素失活。机理是:实验证明维生素C注射液中的每一种成分(因为维生素C注射液在制剂过程中还加入一些附加剂,如焦亚硫酸钠等)都能影响氨苄青霉素的稳定性。处置,维生素C不宜加入含氨苄青霉素输液中,应以另法补充。对此,笔者提出几点异议供作者参考。 1.药典规定维生素C注射液pH5～7,10%葡萄糖注射液pH3.5～5.5,一般只会随着维生素C注射液的加入而使输液pH值提高,使输液pH值降低的
“Unreasonable drug analysis of 200 cases” (hereinafter referred to as “200 cases ”) The seventh prescription is: Ampicillin injection 2.0 Vitamin C injection 3.0 10% glucose injection 1000ml / Author analysis: Ampicillin and vitamin C Mix in 10% glucose infusion, inactivating penicillin due to decreased pH. Mechanism is: Experiments show that vitamin C injection of each component (because vitamin C injection in the formulation process also add some additives, such as sodium metabisulfite, etc.) can affect the stability of ampicillin. Disposal, vitamin C should not be added with ampicillin infusion should be supplemented by another method. In this regard, I made a few objections for the author’s reference. 1. Pharmacopoeia prescription Vitamin C injection pH5 ~ 7, 10% glucose injection pH3.5 ~ 5.5, generally only with the addition of vitamin C infusion infusion pH increased, the infusion pH value decreased