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目的:调查常州市围产儿出生缺陷(BD)的发生情况,了解其相关危险因素,为预防决策提供依据。方法:将2008年BD情况与2004~2007年进行比较,对近年实施干预措施的效果进行评估。结果:常州市5年共有围产儿184 394例,发生BD儿1 081例,BD发生率5.86‰,前3位为唇腭裂、多指、先心病;2008年BD发生率4.82‰,前3位为先心病、多指、唇腭裂。BD的发生无产母年龄差异,无男女性别差异,但有季节性差异。结论:在常州市加强了免费婚检力度,提高产前诊断水平,2008年BD发生率显著下降(P<0.05),且BD顺位发生了变化。采取综合干预措施可达到降低BD发生率的目的。
Objective: To investigate the occurrence of perinatal infant birth defects (BD) in Changzhou, understand the related risk factors and provide evidence for prevention and control. Methods: The 2008 BD situation compared with 2004 ~ 2007, to assess the effect of the implementation of interventions in recent years. Results: There were 184 394 cases of perinatal children in Changzhou city in 5 years. The incidence of BD was 1 081 cases, the incidence of BD was 5.86 ‰. The first 3 cases were cleft lip and palate, multiple fingers and congenital heart disease. The incidence of BD in 2008 was 4.82 ‰, As the first heart disease, multi-finger, cleft lip and palate. There was no gender difference in males and females, but there were seasonal differences. Conclusion: The rate of premarital diagnosis was increased in Changzhou City. The incidence of BD was significantly decreased in 2008 (P <0.05), and the changes of BD sequence were also observed. To take comprehensive interventions can achieve the purpose of reducing the incidence of BD.