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目的：了解间变性大细胞淋巴瘤与埃泼斯坦－ 巴尔（ Ｅ Ｂ） 病毒的关系。方法：采用原位杂交及免疫组化 Ｌ Ｓ Ａ Ｂ 法对１２ 例间变性大细胞淋巴瘤（ Ａ Ｌ Ｃ Ｌ） 进行 Ｅ Ｂ Ｖ 编码的 Ｒ Ｎ Ａ（ Ｅ Ｂ Ｅ Ｒｓ） 及 Ｅ Ｂ Ｖ 潜伏膜蛋白（ Ｌ Ｍ Ｐ１） 和潜在膜抗原（ Ｅ Ｂ Ｎ Ａ２） 检测。结果：本组１２ 例 Ａ Ｌ Ｃ Ｌ 中 Ｅ Ｂ Ｅ Ｒｓ 阳性率为２５％ （３／１２） ；１２ 例 Ａ Ｌ Ｃ Ｌ Ｌ Ｍ Ｐ１ 检出率为８．３％ ， Ｅ Ｂ Ｎ Ａ２ 检出率为０（０／ １２） ；１２ 例 Ａ Ｌ Ｃ Ｌ 免疫表型，８ 例为 Ｔ 源性，３ 例为 Ｂ 源性，１ 例非 Ｂ 非 Ｔ；１２ 例 Ｂｅｒ Ｈ２ 均阳性。结论：本结果表明 Ｅ Ｂ 病毒感染与部分 Ａ Ｌ Ｃ Ｌ 关系密切，可能在其发病中起着重要作用。
Objective: To understand the relationship between anaplastic large cell lymphoma and the Epstein-Barr virus. METHODS: E B V-encoded R N A (E B E Rs) and E B V latency for 12 degenerative large cell lymphomas (ALC L) using in situ hybridization and immunohistochemical L S A B methods. Membrane Proteins (L M P1) and Latent Membrane Antigens (E B N A2) Assays. Results: The positive rate of E B E Rs in 12 cases of A L C L in this group was 25% (3/12); the detection rate of A L C L L M P1 in 12 cases was 8.3%, and E B N A2 was detected. The rate was 0 (0/12); 12 cases had an A L C L immunophenotype, 8 cases were T-derived, 3 cases were B-derived, and 1 case was non-B non-T; 12 cases of Ber H2 were positive. Conclusion: This result shows that E B virus infection is closely related to some A L C L and may play an important role in its pathogenesis.