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二氟一氯甲烷(F_(22))裂解残液组分极为复杂,而引起吸入急性中毒的主要是该残液气相部分中一些碳氟化合物的混合气体。1974年上海第一医学院华山医院报告9例,其主要表现为化学性肺炎和肺水肿,其中3例因肺组织急性纤维化呼吸功能衰竭而死亡。有机氟急性中毒的治疗目前尚无特效药物。本文选用哌啶对F_(22)裂解残液气体吸入急性中毒动物模型作实验治疗。治疗用哌啶为10mg/ml的哌啶盐酸溶液,用药量兔腹腔注射30mg/kg(治疗和对照组各47只家兔),肌肉注射45mg/kg(治疗和对照组各20只家兔);狗静脉注射13mg/kg(治疗、对照组各9只狗),肌肉注射18mg/kg(治疗、对照组各
The composition of the difluorochloromethane (F_ (22)) cleavage raffinate is extremely complex and the main cause of acute inhalation toxicity is the mixture of some fluorocarbons in the gas phase of the raffinate. In 1974, Huashan Hospital of Shanghai First Medical College reported 9 cases, which mainly manifested as chemical pneumonitis and pulmonary edema, of which 3 died of pulmonary fibrosis due to respiratory failure. The treatment of organic fluorine acute poisoning currently no effective drugs. In this paper, piperidine was used to treat experimental animal model of acute poisoning induced by F_ (22) pyrolysis gas. The treatment group was treated with piperidine hydrochloride solution (10mg / ml) and intraperitoneal injection of 30mg / kg (47 rabbits in each group) and 45mg / kg intramuscular injection (20 rabbits in each group) ; Dog intravenous injection of 13mg / kg (treatment, control group of 9 dogs), intramuscular injection of 18mg / kg (treatment, control group