细菌对抗宿主细胞免疫应答从而引起慢性感染的机制很少报告。本文作者在以前的研究中曾发现致病性大肠埃希菌(EPEC)产生一种高Mr、对蛋白酶敏感的物质,这种物质在淋巴细胞受刺激时可以选择性地抑制IL-2、IL-4和IFN-γ的产生,并对这些淋巴细胞的增殖有抑制作用。因此,作者将这种物质称为淋巴细胞抑制因子(LIF)。LIF对淋巴细胞的抑制作用与抗原刺激、丝裂原作用及CD3交联体等因素无关,对淋巴细胞以外 The mechanisms by which bacteria fight host cell immune responses and cause chronic infections are rarely reported. In previous studies, the authors found that pathogenic E. coli (EPEC) produces a highly Mr, protease-sensitive substance that selectively inhibits IL-2, IL when stimulated by lymphocytes -4 and IFN-γ production, and the proliferation of these lymphocytes inhibited. Therefore, the authors call this substance lymphocyte inhibitory factor (LIF). The inhibitory effect of LIF on lymphocytes has nothing to do with antigen stimulation, mitogen and CD3 cross-linked and other factors, on the outside of lymphocytes