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目的:通过对慢性乙肝肝炎患者血液中谷丙转氨酶(ALT)高低的检测,来对患者的肝组织炎症进行判别。方法:本文选取了从2011年1月-2013年1月期间在本院治疗的253例乙型肝炎患者,通过对肝组织的HE染色还有其他的肝穿活检的治疗过程,在通过普通的光学显微镜对肝脏表面活动的各种情况进行观察分析。在进行肝脏组织的活性检测之前,对患者进行连续一个月的血清里面的谷丙转氨酶的活性检测,并记录相应的值。结果:通过对研究资料的进行分析工作,显示慢性乙型肝炎患者血清中的谷丙转氨酶活性越高,患者的肝组织炎性活动度和纤维化的程度就会越严重,尤其是在肝炎的中度和重度患者上,差异就更加显著,并且有生物学统计意义,同时也符合病理诊断的结果。结论:通过对慢性乙型肝炎患者的血清中的ALT进行检测,就表明慢性乙肝患者中血清ALT指标可以作为诊断肝组织炎症活动度和纤维化程度的一个指标,在临床上有很大的意义,值得临床上的应用。
OBJECTIVE: To determine the degree of hepatic inflammation in patients with chronic hepatitis B by detecting the level of alanine aminotransferase (ALT) in the blood. METHODS: This study selected 253 patients with hepatitis B who were treated in our hospital from January 2011 to January 2013. Hepatic tissue was stained by HE and other biopsy specimens were obtained through routine Light microscopy on the surface of the liver activities were observed and analyzed. The patient was tested for activity of alanine aminotransferase in the serum for one month before conducting the liver tissue activity test, and the corresponding value was recorded. Results: Analysis of research data showed that the higher the alanine aminotransferase activity in the serum of patients with chronic hepatitis B, the more severe the degree of liver tissue inflammatory activity and fibrosis in patients, especially in hepatitis Moderate and severe patients, the difference is even more significant, and biologically meaningful, but also consistent with the results of pathological diagnosis. Conclusion: The detection of serum ALT in patients with chronic hepatitis B indicates that the serum ALT index in patients with chronic hepatitis B can be used as an index to diagnose the degree of inflammation activity and fibrosis in liver tissue, and has great clinical significance , It is worth clinical application.