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用５％乙酸提取人子宫颈粘液可溶物，经电泳凝胶琼脂糖弥散法抗菌试验发现，子宫颈粘液酸溶性提取物有两条主带对致病性大肠杆菌２５９２２株和金葡球菌２５９２３株有强抗菌活性，并分别命名为Ｈｃｐ－１和Ｈｃｐ－２。经Ｔｒｉｃｉｎｅ－ＳＤＳ－ＰＡＧＥ电泳分析，Ｈｃｐ－１分子量为６．７ｋｄ、１０ｋｄ和１５．４ｋｄ，Ｈｃｐ－２分子量为４．４ｋｄ、６．７ｋｄ、９ｋｄ和１５．４ｋｄ，均为多肽混合物。实验结果提示子宫颈粘膜能合成一类抗菌多肽，在子宫颈抗菌机理中发挥重要作用。
Human cervical mucus soluble material was extracted with 5% acetic acid. The antibacterial test of electrophoretic gel agarose diffusion assay showed that there were two main bands of acid-soluble extract of cervical mucus against pathogenic Escherichia coli 25922 and Staphylococcus aureus 25923 Strain has strong antibacterial activity, and were named Hcp-1 and Hcp-2. The molecular weight of Hcp-1 was 6.7kd, 10kd and 15.4kd, and the molecular weight of Hcp-2 was 4.4kd, 6.7kd, 9kd and 15.4kd by Tricine-SDS-PAGE. Experimental results suggest that cervical mucosa can synthesize a class of antimicrobial peptides, which play an important role in the antimicrobial mechanism of cervix.