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目的:探讨不同的超排卵方案对多囊卵巢综合征(PCOS)患者实施IVF-ET治疗过程的影响。方法:回顾分析行IVF治疗、长方案超促排卵的PCOS患者134个移植周期,比较分析不同超促排卵方案、促排卵药物的IVF-ET结局。结果:①递增方案组(n=7,6)总Gn使用量明显大于递减方案组(n=74)、Coasting方案组(n=16)和恒量方案组(n=18)(P<0.05)。②后期添加hMG组(n=61)总Gn使用量明显大于单用FSH组(n=73)(P<0.05),着床率也明显降低(P<0.05),但临床妊娠率无显著性差异(P=0.064);③普丽康组(n=43)与果纳芬+hMG组(n=22)及普丽康+hMG组(n=39)相比,总Gn使用量明显减少(P<0.05),而与果纳芬组(n=30)间无统计学差异;普丽康组与普丽康+hMG组相比,获卵数明显增加(P<0.05)。结论:PCOS患者的长方案超排卵方案中,递增方案增加了Gn使用总量而临床妊娠率有偏低的趋势;添加hMG不能提高着床率和临床妊娠率;单纯普丽康超排卵有减少总Gn使用量,增加获卵数的趋势。
Objective: To investigate the effect of different ovarian hyperstimulation programs on IVF-ET in patients with polycystic ovary syndrome (PCOS). Methods: Retrospective analysis of IVF treatment, long-term super-ovulation PCOS patients with 134 cycles, comparative analysis of different ovulation induction programs, ovulation induction IVF-ET outcome. Results: (1) The total Gn usage in the incremental regimen group (n = 7,6) was significantly higher than that in the decreasing regimen group (n = 74), the Coasting regimen group (n = 16) and the constant regimen group (n = 18) . (2) The total Gn usage was significantly higher in hMG group (n = 61) than that in FSH group (n = 73) (P <0.05), and the implantation rate was significantly lower (P <0.05) (P = 0.064); ③ The total Gn consumption in the Prolid group (n = 43) was significantly lower than that in the fruitnafen + hMG group (n = 22) and the Prolid + hMG group (P <0.05), but there was no significant difference between them (P <0.05) and the group of noggin (n = 30). The number of oocytes retrieved in the Prolid group was significantly higher than that in the Priconcon + hMG group (P <0.05). CONCLUSIONS: In the long-term regimen of ovarian hyperstimulation in patients with PCOS, the increasing regimen increases the total amount of Gn used while the clinical pregnancy rate tends to be low. Adding hMG can not improve the implantation rate and clinical pregnancy rate; there is a decrease in the single- Total Gn usage, increasing the number of oocytes.