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本文报告某粘胶纤维厂97名接触二硫化碳工人肾功能检查结果。调查期间该厂工作场所空气中二硫化碳浓度为10.8～53mg/m~3。59名目前仍密切接触二硫化碳工人班末尿2-硫代噻唑烷-4-羧酸几何均数为4.94mg/g肌酥,范围在1.81～12.42mg/g肌酐。接触组尿蛋白几何均数为57.9mg/g肌酐,略高于对照组,但无统计学差异。接触组尿β_2-微球蛋白几何均值为188μg/g肌酐,明显高于对照组(P<0.01),若除外高血压者,则68例血压正常的二硫化碳作业工人尿β_2-微球蛋白几何均值与对照组相比,差异无显著性。接触组尿蛋白和/或β_2-微球蛋白超过正常上限的有13例,其中12例有高血压病史,1例患肾结石,13例肾功能异常者的年龄均在40岁以上。由于高血压个例与接触二硫化碳的因果关系尚难确定,故长期接触二硫化碳和高血压与肾功能异常三者之间的关系尚需进一步研究。
This article reports 97 viscose fiber factory contact with carbon disulfide workers renal function test results. During the investigation, the concentration of carbon disulfide in the workplace air of the factory was 10.8-53mg / m ~ 3.59 and the geometric mean of urinary 2-thiazolidine-4-carboxylic acid was 4.94mg / g muscle Crisp in the range of 1.81 ~ 12.42mg / g creatinine. Urinary protein in the contact group geometric mean of 57.9mg / g creatinine, slightly higher than the control group, but no significant difference. The urinary β_2-microglobulin in the exposed group was 188 μg / g creatinine averagely, which was significantly higher than that in the control group (P <0.01). The mean β 2-microglobulin urinary concentration of 68 normotensive carbon disulfide workers was higher than that of the control group Compared with the control group, the difference was not significant. Thirteen patients were exposed to urinary albumin and / or β_2-microglobulin above the upper limit of normal. Twelve patients had a history of hypertension, one patient had kidney stones, and 13 patients with renal dysfunction were over 40 years of age. Due to the causal relationship between hypertension and exposure to carbon disulfide, it is still difficult to determine the relationship between long-term exposure to carbon disulfide and hypertension and renal dysfunction needs further study.