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目的:探讨抗精子抗体(AsAb)、抗子宫内膜抗体(EmAb)检测在女性不孕症诊断与治疗中的作用。方法:应用酶联免疫吸附试验(ELISA法)对467例不孕症女性进行AsAb与EmAb检测,并与64例健康孕妇检测结果进行对比分析。结果:不孕组患者AsAb、EmAb检测阳性率明显高于对照组,组间比较差异显著(P<0.05);原发性不孕患者中AsAb、EmAb检测阳性无明显相关性。结论:AsAb和EmAb检测可为女性免疫性不孕患者的诊断与治疗提供重要依据,可作为女性不孕症常规检测项目。
Objective: To investigate the role of anti-sperm antibody (AsAb) and anti-endometrial antibody (EmAb) in the diagnosis and treatment of female infertility. Methods: AsAb and EmAb were detected in 467 infertile women by enzyme-linked immunosorbent assay (ELISA), and compared with 64 healthy pregnant women. Results: The positive rates of AsAb and EmAb in infertility group were significantly higher than those in control group (P <0.05). There was no significant correlation between AsAb and EmAb in infertile patients. Conclusion: AsAb and EmAb test may provide an important basis for the diagnosis and treatment of female infertility patients, and can be used as a routine test item of female infertility.