大鼠35只,性别不分,体重一般在160～250克之间,石英粉尘采用中国科学院卫生研究所经酸处理的粉尘,分散度小于5微米者占90%以上。动物经乙醚轻度麻醉,采用气管非暴露法一次注入尘悬液1毫升(每毫升悬液含石英尘50毫克)造成实验矽肺。按体重顺序随机分成五组,每组动物七只,其中雄性四只,雌性三只, Thirty-five rats, regardless of sex, were generally between 160 and 250 grams in weight. Quartz dust was treated with acid-treated dust from the Institute of Health Sciences of the Chinese Academy of Sciences. More than 90% of the dispersion was less than 5 microns. The animals were lightly anesthetized with ether, and 1 ml of a dust suspension (50 mg of quartz dust per milliliter of suspension) was injected once using a non-exposed trachea method to cause an experimental silicosis. According to the weight sequence, they were randomly divided into five groups of seven animals per group, including four males and three females.