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替硝唑是继甲硝唑后研制成功的疗效高、疗程短、耐受性好的抗滴虫药物。对阴道滴虫、阿米巴等原生动物具有较高的省略,对厌氧菌群如产黑色素类杆菌群、脆弱类杆菌、梭形杆菌均有较强的抑菌杀菌作用。替硝唑用于牙周炎、冠周炎治疗总有效率高达97.1％,明显高于甲硝唑。本文实验测定替硝唑、甲硝唑对6株口腔重要厌氧菌的国际标准菌株的最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。评价其对口腔优势厌氧菌的抑菌性能。
Tinidazole is following the successful development of metronidazole curative effect of high efficacy, short course, well tolerated anti-trichomonad. Trichomonas vaginalis, amebias and other protozoa with a high omission of the anaerobic bacteria such as melanin-producing group of bacteria, Bacteroides fragilis, Fusobacterium have a strong antibacterial effect. Tinidazole for periodontitis, pericoronitis treatment of the total effective rate as high as 97.1%, significantly higher than metronidazole. In this paper, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of tinidazole and metronidazole against 6 international standard strains of oral anaerobic bacteria were determined experimentally. To evaluate its antibacterial activity against oral anaerobic bacteria.