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采用6-烷硫基吡啶化合物为原料,用N,N-二甲基甲酰胺(DMF)为溶剂,双氧水为氧化剂,水合钨酸钠为催化剂,经过一步氧化变成6-烷砜基多取代吡啶化合物,再在醇钠或碳酸钾的催化作用下与醇或酚反应生成含烷(芳)氧基的多取代吡啶衍生物.通过~1H NMR,EI-MS,IR,元素分析等方法对所合成的化合物进行了结构表征.代表化合物2-甲基-4-氨基-5-氰基-6-(3-硝基苯氧基)烟酸甲酯经单晶X衍射确证了结构.对合成的含6-烷(芳)氧基多取代吡啶衍生物作了初步的除草活性测试,测试结果表明:含6-烷(芳)氧基多取代吡啶衍生物对油菜和稗草具有一定的除草活性,且化合物对油菜和稗草根的抑制优于对茎的作用,表现出明显的选择性.
Using 6-alkylthiopyridine compound as raw material, N, N-dimethylformamide (DMF) as solvent, hydrogen peroxide as oxidant and sodium hydratate as catalyst, one step oxidative conversion to 6-alkylsulfonyl poly-substituted Pyridine compounds, and then react with alcohol or phenol in the presence of sodium alcoholates or potassium carbonate to form poly-substituted pyridine derivatives containing alkane (aryl) oxy group. By means of 1H NMR, EI-MS, IR and elemental analysis The structure of the synthesized compounds was confirmed by X-ray diffraction. The structure of the compound methyl 2-methyl-4-amino-5-cyano-6- (3-nitrophenoxy) The preliminary test of herbicidal activities of the synthesized 6-alkylated polypyridine derivatives showed that the pyridine derivatives containing 6-alkyloxy groups had the highest herbicidal activity on rapeseed and barnyardgrass Herbicidal activity, and compound inhibition of rapeseed and barnyardgrass roots better than the role of the stem, showing obvious selectivity.