社会、心理压力与疾病的发生、发展及转归有着密切的联系。而社会、心理压力为什么会导致一些心身疾病的发生?为什么可使一些疾病加重?尚无满意答案。本文选用自发性高血压大鼠(SHR),在实验室应激的条件下,对比观察了动物的血压,并对其作用机制进行了初步探讨。发现:心理紧张状态可以导致有高血压遗传素质的SHR提前发病,而且可使病情不断加重;应激后SHR血浆神经递质(NE.E)和神经肽类物质(VIP)均明显增高。表明原发性高血压病的发生、发展与社会心理因素关系密切。 Social, psychological stress and disease occurrence, development and outcome are closely linked. And social, psychological stress, why can lead to some psychosomatic diseases? Why can some diseases aggravate? There is no satisfactory answer. In this paper, spontaneous hypertensive rats (SHR) were selected to observe the blood pressure of animals under laboratory stress conditions, and its mechanism of action was discussed. It was found that the state of psychological stress could lead to the early onset of SHR with genetic predisposition of hypertension and aggravate the disease. The levels of plasma neurotransmitter (NE.E) and neuropeptide (VIP) in SHR were significantly increased after stress. Show that the occurrence and development of essential hypertension and social psychological factors are closely related.