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采用固相放射免疫分析法 (RIA)和双抗体夹心酶联免疫法 (EL ISA) ,对多发性骨髓瘤 (MM)患者进行血清白细胞介素 2 (IL- 2 )、白细胞介素 2受体 (s IL- 2 R)、白细胞介素 6 (IL- 6 )、白细胞介素 6受体 (s IL- 6 R)检测 ,并进行长期随访。结果 MM患者血清 IL- 2、s IL- 2 R和 IL- 6、s IL- 6 R水平明显升高 ,IL-2与 ﹀2 微球蛋白 (﹀2 - MG)呈负相关 ,IL- 6、s IL- 6 R与 ﹀2 - MG呈正相关。初诊时血清 s IL- 6 R升高者疗效较差 ,IL- 2升高者预后较好。
The levels of serum interleukin 2 (IL-2), interleukin 2 receptor (IL-2) and interleukin 2 receptor (IL-2) were measured in patients with multiple myeloma (MM) by solid phase radioimmunoassay (RIA) and double antibody sandwich enzyme-linked immunosorbent assay (sIL-2 R), interleukin 6 (IL-6) and interleukin 6 receptor (sIL-6 R) were measured and followed up for a long time. Results The levels of IL-2, IL-2R, IL-6 and IL-6R were significantly increased in patients with MM, but negatively correlated with IL-2 and ﹀2-MG , S IL-6 R and ﹀2 - MG was positively correlated. Initial diagnosis of elevated serum IL-6R ineffective, elevated IL-2 patients with better prognosis.