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目的 :探讨 型胶原酶活性与胃癌浸润、转移的关系。方法 :以 L itta方法测定了 5 5例胃癌患者、2 5例胃溃疡及 2 0例健康对照者血清 型胶原酶的活性。结果 :胃癌患者血清 型胶原酶活性 (12 5 2 .4± 2 32 .1) m U显著高于胃溃疡和对照组 (2 80 .1± 2 5 .1) m U和 (2 78.4± 34 .0 ) m U,P<0 .0 0 1;局部浸润转移组显著高于无浸润组(971.1± 16 1.4) m U,(5 6 0 .2± 6 3.0 ) m U,P<0 .0 5 ;远处转移组显著高于局部浸润转移组 (1882 .5± 2 6 1.2 ) m U,(971.1± 16 4.1) MU,P<0 .0 1。结论 :血清 型胶原酶活性是判断胃癌预后的一个有用指标 ,检测 型胶原酶活性具有重要的临床意义。
Objective : To investigate the relationship between collagenase activity and invasion and metastasis of gastric cancer. Methods : The serum collagenase activity of 55 gastric cancer patients, 25 gastric ulcer patients and 20 healthy controls were measured by Liteta method. RESULTS: The serum serotype collagenase activity (12 5 2 .4 ± 2 32 1.) m U was significantly higher in patients with gastric cancer than in gastric ulcers and controls (2 80.1 ± 25.1) m U and (2 78.4 ± 34). (1) m U, P <0. 0 01; the local infiltration and metastasis group was significantly higher than the non-invasion group (971.1 ± 16 1.4) m U, (5 6 0.2 ± 6 3.0) m U, P <0. The distant metastasis group was significantly higher than that of the local infiltration and metastasis group (1882 ± 5.26 ± 1.2) m U, (971.1 ± 164.1) MU, P <0.01. Conclusion : The activity of serum collagenase is a useful index for judging the prognosis of gastric cancer. The detection of collagenase activity has important clinical significance.