骨性关节炎(OA)是最常见的肌肉骨骼系统疾病,是一种慢性进展性的疾病,主要表现为关节软骨的丢失,关节滑液的炎症,软骨下骨硬化和囊肿形成,骨赘形成,关节疼痛或活动受限。在OA的发病过程中包括炎症因素[1,2]、创伤因素[2]、老龄化[2]、肥胖[2,3],软骨细胞分化[4]、或遗传易感性[2]都可能加速OA的发展。理想动物模型是相对廉价,且能短期内发现差异, Osteoarthritis (OA) is the most common musculoskeletal system disorder and is a chronic progressive disease characterized mainly by loss of articular cartilage, synovial inflammation of the joints, subchondral sclerosis and cyst formation, and osteophyte formation , Joint pain or activity is limited. It is possible that inflammatory factors [1,2], traumatic factors [2], aging [2], obesity [2,3], chondrocyte differentiation [4], or genetic predisposition [2] are involved in the pathogenesis of OA Accelerate the development of OA. The ideal animal model is relatively cheap, and can find differences in the short term,