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抗原免疫(CA_(125))测定法,是近10年来妇科免疫学家研究的一个重要课题。此种抗原组织分布广泛,特异性和准确性较高,可协助妇科疾患的早期诊断,其水平升高或再度升高时,可监测恶性肿瘤及其发展,有利于临床的追踪观察。1 CA_(125)的发现1981年由Bast 等人报告,从1名患者的卵巢浆液性乳头状囊腺癌获得上皮细胞株OVCA_(433),用其免疫小鼠脾细胞,进行杂交产生小鼠单克隆抗体OC_(125),这是一种单克隆免疫球蛋白(IgG)。纯化的
Antigen immunoassay (CA 125) assay is an important issue for gynecologists and immunologists in recent 10 years. The wide distribution of antigenic tissue, specificity and accuracy of higher, can assist in the early diagnosis of gynecological diseases, the level of its rise or re-rise, the monitoring of malignant tumors and its development, is conducive to clinical follow-up observation. 1 Discovery of CA 125 In 1981, Bast et al. Reported that epithelial cell line OVCA_ (433) was obtained from one patient with ovarian serous papillary cystadenocarcinoma, which was used to immunize mouse splenocytes and hybridized to produce mouse Monoclonal antibody OC_ (125), a monoclonal immunoglobulin (IgG). Purified