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Hormones and their receptors regulate cell growth,differentiation and apoptosis and also play important rolesin immune function.Recent studies on the subfamily of the orphan nuclear receptors known as retinoid-acidrelated orphan receptors (ROR) have shed important insights on the roles of this group of nuclear proteins inthe development and function of the immune system.RORα regulates inflammatory cytokine production inboth innate and adaptive immune system while RORγ regulates the normal development of T lymphocyterepertoire and secondary lymphoid organs.Cellular & Molecular Immunology.2004;1(6):401-407.
Hormones and their receptors regulate cell growth, differentiation and apoptosis and also play important roles in immune function. Recent studies on the subfamily of the orphan nuclear receptors known as retinoid-acid related orphan receptors (ROR) have shed important insights on the roles of this group of nuclear proteins inthe development and function of the immune system. ORa regulates inflammatory cytokine production in innate and adaptive immune system while ROR gamma regulates the normal development of T lymphocyte characteristics and secondary lymphoid organs. Cellular & Molecular Immunology. 2004; 1 (6): 401- 407.