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研究目的小儿哮喘时一氧化氮的作用机制及临床意义。研究方法哮喘患儿３３例，正常健康儿童２０例为对照组。测定一氧化氮（ＮＯ）水平及ｃＧＭＰ水平，并对测定结果进行统计学分析。研究结果所有哮喘患儿血浆ＮＯ及ｃＧＭＰ水平在治疗前均明显高于正常儿童（Ｐ均＜０．００１），其中９例重度哮喘患儿血浆ＮＯ水平较２４例轻中度哮喘患儿更高（Ｐ＜０．００１）；治疗后血浆ＮＯ及ｃＧＭＰ水平均恢复正常。结论哮喘发作时一氧化氮产生过多，发挥其细胞及组织毒性作用，使肺上皮细胞等损伤，从而引起和加重哮喘发病，且血浆ＮＯ水平与哮喘病情密切相关。
Objective To investigate the mechanism of nitric oxide in pediatric asthma and its clinical significance. Methods 33 cases of asthma children, 20 cases of normal children as control group. The levels of nitric oxide (NO) and cGMP were measured and the results were statistically analyzed. Results Plasma NO and cGMP levels in all asthmatic children before treatment were significantly higher than those in normal children (all P <0.001), of which 9 children with severe asthma had higher plasma NO levels than 24 children with mild to moderate asthma (P <0.001). After treatment, plasma NO and cGMP levels returned to normal. Conclusions During the asthma attack, nitric oxide is produced excessively, exert its cytotoxic effect on cells and tissues and cause damage to the lung epithelial cells, which causes and aggravates asthma. The plasma NO level is closely related to asthma.