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采用ABC酶标法,观察了菜豆凝集素(PHA)在胃癌组织中的受体表达和分布,探讨胃癌的组织发生与凝集素受体表达的关系以及凝集素对胃癌的诊断价值。结果表明:胃癌组织中PHA受体的阳性率为86.5%,明显高于胃良性疾病组(61.2%),和正常胃粘膜(0),PHA受体的分布与胃癌的病理分型和分化有关。提示PHA是一种有价值的胃癌标记物,对PHA受体过表达的患者进行胃镜病理随访,将有助于提高早期胃癌的检出率。
ABC enzyme-labeled method was used to observe the expression and distribution of PHA in gastric cancer tissues, and to explore the relationship between the histogenesis of gastric cancer and the expression of lectin receptors and the diagnostic value of lectin for gastric cancer. The results showed that the positive rate of PHA receptor in gastric cancer was 86.5%, which was significantly higher than that in benign gastric disease group (61.2%), normal gastric mucosa (0), distribution of PHA receptor and pathological score of gastric cancer. Type is related to differentiation. It is suggested that PHA is a valuable gastric cancer marker. Pathological follow-up of PHA receptor overexpressed patients will help improve the detection rate of early gastric cancer.