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研究目的探讨脂质过氧化作用及其抗氧化酶防御系统在精神分裂症的发生与发展过程中的作用。研究背景近年来,国外初步研究发现精神分裂症患者的自由基及其抗氧化酶防御系统有显著改变,目前这方面的研究国内报道较少。研究方法对66例精神分裂症患者和36例正常人均抽取空腹静脉血,分离血清,用荧光法测定其过氧化脂质(LPO)含量和谷胱甘肽过氧化物酶(GPX)活性,用Pvrogallol—NBT法测定超氧化物歧化酶(SOD)活性,对比分析三项指标的变化及其与病期的关系。统计学处理采用t检验及相关分析。结果精神分裂症患者血清LPO含量和SOD活性均明显高于正常人(P<0.05,P<0.01),GPX活性明显低于正常人(P<0.01);LPO与病期呈正相关(r=0.34,P<0.01),SOD与病期呈负相关(r=-0.359,P<0.01),GPX与病期无显著相关(r=-0.183,P>0.05)。结论精神分裂症患者体内自由基产生增加,由此导致脂质过氧化作用增强,且随病期延长进一步加重。
The purpose of this study was to investigate the role of lipid peroxidation and its antioxidant enzyme defense system in the pathogenesis and development of schizophrenia. Research Background In recent years, preliminary studies abroad found that patients with schizophrenia free radicals and antioxidant enzyme defense system has significantly changed, the current research in this area less reported. Methods Sixty-eight schizophrenic patients and 36 normal individuals were drawn fasting venous blood, the serum was separated, the content of lipid peroxidation (LPO) and glutathione peroxidase (GPX) The activity of superoxide dismutase (SOD) was measured by Pvrogallol-NBT method. The change of three indexes and the relationship with the disease stage were comparatively analyzed. Statistical analysis using t test and correlation analysis. Results Serum LPO content and SOD activity in schizophrenia patients were significantly higher than those in normal controls (P <0.05, P <0.01) and GPX activity was significantly lower than that in normal controls (P <0.01). LPO was positively correlated with disease stage (r = 0.34 , P <0.01). There was a negative correlation between SOD and disease stage (r = -0.359, P <0.01). There was no significant correlation between GPX and disease stage (r = -0.183, P> 0.05). Conclusion In patients with schizophrenia, free radical production increases, leading to increased lipid peroxidation and further aggravating with the prolongation of the disease duration.