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目的:观察肉桂不同部位对大鼠凝血功能及血液流变学的影响,并筛选出活性部位。方法:(1)大鼠连续给药1周后检测凝血功能指标。(2)大鼠连续给药8 d,于第7天皮下注射盐酸肾上腺素再施以冰水浸泡制作急性血淤模型大鼠,次日测定血液流变学指标。结果:(1)肉桂石油醚部位与其他部位比较活性最强,与空白组比较能延长大鼠PT、APTT、TT(P<0.05)。(2)肉桂石油醚组能降低大鼠的全血黏度及全血还原黏度(P<0.01),提高红细胞变形指数(P<0.05)。结论:肉桂石油醚部位为活性部位,能延长大鼠凝血时间,降低血液黏度,具有抗凝和活血化淤的功效。
Objective: To observe the different parts of cinnamon on coagulation and hemorheology in rats, and select the active site. Methods: (1) After 1 week of continuous administration, the indexes of coagulation were detected. (2) After continuous administration of 8 days, rats were subcutaneously injected with epinephrine hydrochloride on the 7th day and then immersed in ice water to make acute blood stasis model rats. The hemorrheological indexes were measured on the next day. Results: (1) The fraction of petroleum ether of cinnamon was the strongest compared with other parts. Compared with the blank group, PT, APTT, TT of TT could be prolonged (P <0.05). (2) Cinnamon petroleum ether group can reduce the whole blood viscosity and whole blood reducing viscosity (P <0.01), improve the erythrocyte deformation index (P <0.05). Conclusion: Cinnamon petroleum ether site is the active site, which can prolong the clotting time of rats, reduce blood viscosity, and has the effect of anticoagulant and blood stasis.