Epostane是合成的甾体激素,在体内可通过竞争抑制3β—羟甾脱氢酶△4—5异构酶系统,使孕酮合成减少,无活性的孕酮前体孕烯醇酮增加。作者采用随机双盲临床试验,观察了Epostane对前列腺素中期引产的临床和生理效应。10例健康初孕妇,孕期13～18周。5例连续服用Epostane3天,每天3次,每次100mg,5例服安慰剂作对照。最后一片药在入院当天的清晨服 Epostane is a synthetic steroid hormone that inhibits progesterone synthesis by inhibiting competitively the 3β-hydroxysteroid dehydrogenase △ 4-5 isomerase system in vivo, with an increase in progesterone, an inactive progesterone precursor. The authors used a randomized double-blind clinical trial to observe the clinical and physiologic effects of Epostane on mid-term induction of prostaglandin. 10 cases of early pregnant women, pregnancy 13 to 18 weeks. 5 consecutive patients taking Epostane 3 days, 3 times a day, each 100mg, 5 placebo for control. The last pill is in the morning service on the day of admission