We investigate the effect of ionizing radiation on gene transfer efficiency and the effect of adenoviral-mediated exogenous P53 overexpression on radiosensitivity of radioresistant human melanoma cell line A375 with wild type p53. Control vector, a replication deficient recombinant adenoviral vector containing a CMV promoter and We investigate the effect of ionizing radiation on gene transfer efficiency and the effect of adenoviral-mediated exogenous P53 overexpression on radiosensitivity of radioresistant human melanoma cell line A375 with wild type p53. Control vector, a replication deficient recombinant adenoviral vector containing a CMV promoter and