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目的:探讨包头地区过氧化物酶体增殖体受体γ2(PPAR-γ2)Pro12Ala基因多态性与2型糖尿病(2DM)并发冠心病(CHD)的相关性。方法:入选对象242例,其中2DM患者48例,2DM并发CHD患者49例,CHD患者45例,另设正常对照组100例。应用聚合酶链反应-限制性片段长度多态性分析进行基因型测定。结果:2DM并发CHD患者基因变异频率明显高于正常对照组(χ2=4·08,P<0·05)。PPAR-γ2Pro12Ala等位基因携带者(X/A型)是2DM并发CHD的独立危险因素,OR=2·457,95%CI=1·596~3·782。结论:包头地区PPAR-γ2Pro12Ala等位基因可以增加一般人群2DM并发CHD的患病风险。
Objective: To investigate the association of PPAR-γ2 Pro12Ala polymorphism with type 2 diabetes mellitus (2DM) complicated with coronary heart disease (CHD) in Baotou area. Methods: A total of 242 patients were enrolled, including 48 patients with 2DM, 49 patients with 2DM complicated with CHD, 45 patients with CHD and 100 patients with normal control. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The frequencies of gene mutation in patients with 2DM complicated with CHD were significantly higher than those in normal controls (χ2 = 4.08, P <0.05). The PPAR-γ2Pro12Ala allele (type X / A) was an independent risk factor for 2DM complicated with CHD, OR = 2.457, 95% CI = 1.596 ~ 3.782. Conclusion: The PPAR-γ2Pro12Ala allele in Baotou can increase the prevalence of 2DM complicated with CHD in the general population.