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1例29岁女性为减肥自行服用盐酸二甲双胍500 mg,3次/d。约1年后出现发热伴上腹部不适、呕吐、尿黄、陶土样大便。肝功能检查:丙氨酸转氨酶(ALT)782 U/L,天冬氨酸转氨酶(AST)346 U/L,总胆红素26μmol/L,C反应蛋白23 mg/L。停用盐酸二甲双胍,给予保肝治疗。15 d后复查肝功能:ALT 65 U/L,AST 50 U/L。
A 29-year-old woman took metformin hydrochloride 500 mg three times a day for weight loss. About 1 year after fever with abdominal discomfort, vomiting, urine yellow, clay-like stool. Liver function tests included alanine aminotransferase (ALT) 782 U / L, aspartate aminotransferase (AST) 346 U / L, total bilirubin 26 μmol / L and C-reactive protein 23 mg / L. Stop using metformin hydrochloride to give liver protection treatment. Liver function was examined after 15 days: ALT 65 U / L, AST 50 U / L.