论文部分内容阅读
目的了解2008-2013年山东省神经管缺陷(NTDs)发生率的变化趋势。方法采用以医院为基础的监测方法收集资料,调查对象为孕28周至生后7 d的围产儿,对2008-2013年全省17市出生缺陷监测网监测的673 361例围产儿,129例NTDs病例进行回顾性分析。结果 NTDs发生率由2008年2.9/万下降到2013年的1.5/万,6年下降了48.3%,年下降率10.4%,农村NTDs下降幅度为60.0%,城市为5.6%;脊柱裂、脑膨出发生率分别下降了60.0%和33.3%。结论山东省NTDs发生率呈下降趋势,农村下降幅度大于城市;脊柱裂、脑膨出发生率下降较快。神经管缺陷儿出生素质差,围产期病死率高,预后不良。加强预防和产前诊断是降低发生率的有效措施。
Objective To investigate the change trend of the incidence of neural tube defects (NTDs) in Shandong province from 2008 to 2013. Methods A hospital-based surveillance method was used to collect data on pregnant women from 28 weeks of pregnancy to 7 days of life. Of the 673 361 cases of perinatal children and 129 cases of NTDs monitored by the birth defect monitoring network in 17 provinces in 2008-2013, The cases were retrospectively analyzed. Results The incidence of NTDs decreased from 2.9% in 2008 to 1.5% in 2013, decreased by 48.3% in 6 years and 10.4% in annual decline. The NTDs in rural areas decreased by 60.0% and 5.6% in urban areas respectively. The incidence of spina bifida, The outbreak rates dropped by 60.0% and 33.3% respectively. Conclusions The incidence of NTDs in Shandong Province shows a downward trend, and the drop in rural areas is larger than that in urban areas. The incidence of spina bifida and encephalocele decreases rapidly. Poor quality of life of neural tube defects, high perinatal mortality, poor prognosis. Strengthening prevention and prenatal diagnosis is an effective measure to reduce the incidence.