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目的:了解52例中枢神经系统感染患儿甲状腺功能情况,分析甲状腺功能异常与病情危重度和昏迷之间的关系,以提供临床参考。方法:用化学发光法检测甲状腺功能,并用Glasgow昏迷评分和APACHE行危重病评分评估治疗1周前后的病情。结果:52例患者有22例出现甲状腺功能改变,异常组中,FT3异常者所占比例为73.9%,FT4异常占43.5%,其均值比正常组明显下降,P<0.05。FT3、FT4、TSH均下降者预后较差。甲状腺功能异常组患者昏迷时间比正常组时间长(P<0.05),病情重(P<0.05),预后差。结论:中枢神经系统感染患者应尽早评估甲状腺功能以判断病情,协助评估病情和诊疗。
Objective: To understand the thyroid function of children with central nervous system infection in 52 cases and to analyze the relationship between thyroid dysfunction and critical illness and coma, so as to provide clinical reference. Methods: Thyroid function was detected by chemiluminescence method, and the condition of one week before and after treatment was evaluated by Glasgow coma score and APACHE critical illness score. Results: Twenty-two of 52 patients had thyroid function changes. In abnormal group, the abnormality rate of FT3 was 73.9% and FT4 abnormality was 43.5%. The mean value of FT4 was significantly lower than that of normal group (P <0.05). The decline of FT3, FT4, TSH were poor prognosis. Patients with abnormal thyroid function had longer coma than patients with normal function (P <0.05), severe illness (P <0.05), and poor prognosis. CONCLUSIONS: Patients with CNS infection should assess thyroid function as early as possible to assess the condition and assist in the evaluation of the condition and diagnosis.