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雌激素对许多哺乳动物的抗生育效应显然是一致的,但其作用机理尚未得到满意的阐明。有人认为卵子在管内运行加速,或过量的雌激索干扰了子宫内膜的发育是其抗生育作用的原因,但本文作者前曾证明,雌激素导致大鼠妊娠失败既不是由于促性腺激素分泌不足,也不是由于其分泌过多。本文研究雌激素阻止大鼠受孕是否由于其卵巢水平直接发挥了黄体溶解作用的缘故。选择年龄约4个月的正常的和已切除两侧子宫的大鼠做实验。每天先照12小时。在雌鼠动情前期将确知有生育力的雄鼠与其同笼,以阴道涂片发现有精子的那天作为受孕或假孕的第1天。在受孕的第8天,在乙醚麻醉下剖腹记录胎数。在受孕的第16天,显微解剖胎儿、胎盘及卵巢,并用扭力天平称重。对每组中最大的4个黄体(CL)也作显微
Estrogen is obviously consistent with the anti-fertility effect of many mammals, but its mechanism of action has not yet been satisfactorily elucidated. Some people think that the operation of the egg in the tube accelerated, or excessive estrogen interference with endometrial development is its anti-fertility reasons, but the authors have previously demonstrated that estrogen-induced pregnancy failure in rats is neither due to gonadotropin secretion Not enough, nor is it due to its excessive secretion. This article studies whether estrogen prevents rat pregnancy from directly exerting corpus luteum due to its ovarian level. Rats of normal and excised uterus aged about 4 months were selected for experiments. According to the first 12 hours a day. In the female estrus before the male fertility will be sure to be the same cage, vaginal smear found sperm that day as the first day of conception or pregnancy. On the 8th day of conception, the number of fetuses was recorded by caesarean section under ether anesthesia. On the 16th day of conception, the fetus, placenta and ovary were microdissected and weighed with a torque balance. The largest four corpora lutea (CL) in each group were also microscopically