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目的:⑴了解轻度胃肠炎伴婴幼儿良性惊厥(BICE)的病原分布。⑵分析BICE患儿血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平和外周血白细胞数(WBC)和血红蛋白(Hb)水平，探讨其与BICE发生惊厥是否有相关性。方法:选取2017年5月至2018年5月本院儿内科30例BICE患儿为观察组，同期选择不伴有惊厥发作的轻度胃肠炎患儿30例作为对照组。肠道病毒检测使用胶体金法或荧光PCR法；血清IL-6、TNF-α的检测使用化学发光法。比较对照组和观察组间及不同惊厥发作次数、持续时间BICE患儿间的血清炎症因子、WBC、Hb水平。结果:⑴BICE组发病以秋冬季为主。对照组夏季发病率高于BICE组，差异有统计学意义(n P<0.05)。⑵BICE组30例患儿轮状病毒阳性占46.67%，诺如病毒阳性占6.67%，柯萨奇病毒阳性占10%。⑶BICE组血清IL-6水平[(16.37±11.97)pg/ml]高于对照组[(10.30±6.95)pg/ml]，差异有统计学意义(n P＝0.019)；BICE组血清TNF-α水平[(11.96±7.10)pg/ml]高于对照组[(6.95±4.97)pg/ml]，差异有统计学意义(n P＝0.003)。⑷BICE组惊厥次数≥2次患儿组血清IL-6水平[(24.83±14.34)pg/ml]和TNF-α水平[(16.93±6.73)pg/ml]高于惊厥次数<2次患儿组[IL-6：(11.48±6.91)pg/ml，TNF-α：(9.07±5.66)pg/ml]，差异有统计学意义(n P＝0.013，n P＝0.002)；BICE组惊厥持续时间≥5 min患儿组血清IL-6水平[(27.84±14.42)pg/ml]和TNF-α水平[(18.00±6.74)pg/ml]高于惊厥持续时间0.05)。n 结论:⑴本地区的BICE病原以轮状病毒感染为主。⑵BICE患儿存在一定程度的免疫调节功能紊乱，IL-6和TNF-α可能参与了BICE的惊厥发生过程；血清IL-6、TNF-α水平越高，患儿惊厥程度越重。⑶血常规WBC数和Hb含量与BICE的发生无关。“,”Objective:⑴ To understand the pathogen distribution of mild gastroenteritis with benign infantile convulsion (BICE). ⑵ To analyze the levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), peripheral blood leukocyte count (WBC) and hemoglobin (Hb) in children with BICE, and to explore whether they are related to the convulsion of BICE.Methods:From May 2017 to May 2018, 30 BICE children in the Department of Pediatrics of Inner Mongolia Autonomous Region Maternal and Child Health Hospital were selected as the observation group, while 30 mild gastroenteritis children without convulsion attack were selected as the control group. The detection of enterovirus uses colloidal gold method or fluorescence polymerase chain reaction (PCR) method. Serum IL-6 and TNF-α were detected by chemiluminescence. The levels of serum inflammatory factors, WBC and Hb were compared between the control group and the observation group, as well as between the children with different seizure times and duration.Results:⑴ The onset of BICE group was mainly in autumn and winter. The incidence rate of control group in summer was higher than that in BICE group, with statistically significant difference (n P<0.05). ⑵ In BICE group, rotavirus, norovirus and Coxsackie virus were 46.67%, 6.67% and 10%, respectively. ⑶ The levels of serum [IL-6 (16.37±11.97)pg/ml] and [TNF-α (11.96±7.10)pg/ml] in BICE group were higher than those in control group [IL-6 (10.30±6.95)pg/ml, TNF-α (6.95±4.97)pg/ml], with statistically significant difference (n P=0.019, n P=0.003). ⑷ The levels of serum [IL-6 (24.83±14.34)pg/ml] and [TNF-α (16.93±6.73)pg/ml] in children with convulsion ≥ 2 times were higher than those in children with convulsion < 2 times [IL-6 (11.48±6.91)pg/ml, TNF-α (9.07±5.66)pg/ml], with statistically significant difference (n P=0.013, n P=0.002). The levels of serum [IL-6 (27.84±14.42)pg/ml] and [TNF-α (18.00±6.74)pg/ml] in children with convulsion duration ≥ 5 min were higher than those in children with convulsion duration 0.05).n Conclusions:⑴ Rotavirus infection is the main pathogen of BICE in this region. ⑵ Children with BICE have a certain degree of immune regulation dysfunction. IL-6 and TNF-α may participate in the convulsion process of BICE. The higher the levels of serum IL-6 and TNF-α, the more severe the convulsion degree in children. ⑶ This study shows that WBC number and Hb content in blood routine have nothing to do with the occurrence of BICE.