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肝纤维化是肝脏对各种致病因子(相关肝炎病毒、慢性酒精中毒、脂肪性肝炎等)所致的慢性损伤的一种慢性炎性反应过程,这些致病因子导致炎性反应调控失调,从而引起大量炎性细胞因子释放,如巨噬细胞释放炎性细胞因子——白介素(IL)-1、IL-6和肿瘤坏死因子-α(TNF-α)等,而这些炎性细胞因子与肝纤维化发生、发展有关,其既可激活肝星状细胞(HSC)转变为肌成纤维细胞,也可激活汇管区纤维细胞转变为成纤维细胞。激活的HSC及
Liver fibrosis is a chronic inflammatory reaction of the liver to chronic damage caused by various causative agents (related to hepatitis virus, chronic alcoholism, steatohepatitis, etc.), which lead to disorders in the regulation of inflammatory responses, As a result, a large number of inflammatory cytokines are released, for example, macrophages release inflammatory cytokines such as interleukin (IL) -1, IL-6 and tumor necrosis factor-α (TNF-α) The occurrence and development of liver fibrosis, which can activate hepatic stellate cells (HSC) into myofibroblasts, also can activate the portal area fibroblasts into fibroblasts. Activated HSC and