自噬是一种在正常细胞和病理状态细胞中普遍存在的生理机制。自噬与肿瘤细胞的生存与凋亡关系密切,在很多肿瘤细胞中,其自噬活性均有改变。抑制肿瘤细胞中自噬活动可以促进肿瘤细胞的凋亡。在化疗诱导肿瘤细胞凋亡的同时,以自噬抑制剂抑制肿瘤细胞的自噬活动,可改善肿瘤的治疗效果。 Autophagy is a common physiological mechanism in normal and pathological cells. Autophagy is closely related to the survival and apoptosis of tumor cells, and in many tumor cells, the autophagy activity changes. Inhibition of autophagy in tumor cells can promote tumor cell apoptosis. Chemotherapy induced tumor cell apoptosis at the same time, with autophagy inhibitors inhibit tumor cell autophagy activity, can improve the therapeutic effect of the tumor.