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穿心莲内酯注射液(莲必治注射液)是一种抗菌消炎药。近年发现穿心莲内酯注射液可致急性肾损害,从而引起人们对其安全性的关注;其临床特点为发病时间短,常在用药1次后出现,表现为腰痛、恶心、少尿、无尿、血肌酐及尿素氮升高。实验研究表明,穿心莲内酯注射液对大鼠的肾脏不产生明显毒性,但短期大量给药可致一定程度的肾损害。穿心莲内酯注射液致肾损害可能和其潜在毒性或过敏反应有关。另外,高浓度药液或与肾毒性药物联用易引起肾损害。临床应用穿心莲内酯注射液时应了解患者的既往过敏史,药液浓度和滴注速度应适宜,避免与肾毒性药物联用,肾病患者不宜使用。
Andrographolide injection (Lianbizhi injection) is an antibacterial anti-inflammatory drug. In recent years, it has been found that andrographolide injection can cause acute kidney damage, which causes people to pay attention to their safety; its clinical characteristics are short onset time, often appear after the drug once, manifested as low back pain, nausea, oliguria, anuria Blood creatinine and urea nitrogen increased. Experimental studies have shown that andrographolide injection does not produce significant toxicity in rats’ kidneys, but large doses in the short term can cause a certain degree of renal damage. Kidney damage caused by andrographolide injection may be related to its potential toxicity or allergic reaction. In addition, high concentrations of drugs or in combination with nephrotoxic drugs can cause kidney damage. Clinical application of andrographolide injection should be aware of the patient’s past history of allergies, drug concentration and infusion rate should be appropriate to avoid combination with nephrotoxic drugs, renal patients should not be used.