论文部分内容阅读
研究目的 探讨儿童过度换气(HV)与脑电图变化的临床意义。 研究设计 病例对照研究 患者和参与者 140例过度换气儿童(正常组),男81人,女59人,无惊厥和癫痫个人及家族史。31例有典型临床和脑电图改变的失神及精神运动型发作癫痫(病例组),年龄5～14岁。男12例,女19例。 处理方法 对正常组64例,病例组7例进行HV前、HV后2.5～3分钟、EEG复原和HV停后3～4分钟的静脉血气连续分析,并行脑电图检查和HV前血糖测定。 研究结果 正常组与病例组均有较高的慢活动发生率。正常组中14.6％(20/137)可见慢活动的一过性不对称,而病例组中出现暴发性或局限性慢活动者明显高于对照组(P均<0.01)。正常组和病例组出现早期突破分别为0和16.1％(5/37),差异非常显著(P<0.01)。HV开 始后PaCO_2显著下降,PaO_2轻度下降。正常组和病例组血糖均正常。 结论 HV对失神和精神运动性癫痫有诊断价值。慢波活动是正常儿童HV中常见图像。HV中慢活动与PaCO_2和PaO_2变化并无平行关系。
Objective To investigate the clinical significance of hyperventilation (HV) and electroencephalogram (EEG) in children. Study design Case-control study Patients and participants 140 cases of hyperventilation in children (normal group), 81 males and 59 females, without seizures and epilepsy Individual and family history. 31 patients with typical clinical and electroencephalogram changes in deaf and psychomotor seizures (case group), aged 5 to 14 years. There were 12 males and 19 females. Methods Sixty-four patients in the normal group and 7 patients in the case group underwent continuous venous blood gas analysis before HV, at 2.5-3 minutes after HV, at recovery of EEG and 3-4 minutes after HV-closure. EEG and HV pre-blood glucose were measured. The results of the normal group and the case group had a higher incidence of slow activity. In the normal group, 14.6% (20/137) showed a transient asymmetry of slow activity, while those in the case group were significantly higher than those in the control group (all P <0.01). The early breakthrough of normal group and case group were 0 and 16.1% (5/37) respectively, the difference was significant (P <0.01). PaCO 2 decreased significantly after HV started and PaO 2 decreased slightly. Normal group and case group blood glucose were normal. Conclusions HV is valuable for the diagnosis of deaf and psychomotor epilepsy. Slow wave activity is a common image of normal children’s HV. There is no parallel relationship between slow activity in HV and changes in PaCO_2 and PaO_2.