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应用免疫组化技术，检测了２５例结核病人４９块病变组织中的减毒牛型结核杆菌（ＢＣＧ）抗原、ＩｇＧ、ＩｇＭ、ＩｇＡ及补体Ｃ３ｃ。结果：在大多数结核病变组织中可检测到ＩｇＡ、ＩｇＭ等物质，而以淋巴结的阳性反应较高。ＩｇＧ与ＩｇＭ染色阳性反应分别为８９％（２４／２７）与８７％（１３／２５）。抗－Ｃ３，抗ＩｇＧ、ＩｇＭ等阳性反应物常见于同一结核病灶，ＩｇＭ抗体阳性多位于干酪样坏死灶。研究表明，在结核病的发病过程中，除细胞免疫外，还有体液免疫参与，并表明ＩｇＭ之免疫复合物可能与干酪样坏死的形成有关系。
Immunohistochemistry was used to detect attenuated M. tuberculosis (BCG) antigens, IgG, IgM, IgA, and complement C3c in 49 diseased tissues of 25 tuberculosis patients. Results: IgA, IgM and other substances were detectable in most of the cases with tuberculosis. The positive reaction in lymph nodes was higher. Positive IgG and IgM staining were 89% (24/27) and 87% (13/25), respectively. Anti-C3, anti-IgG, IgM and other positive reactions common in the same tuberculosis, IgM antibody positive mostly in caseous necrosis. Studies have shown that in addition to cellular immunity, there is humoral immunity involved in the pathogenesis of tuberculosis and suggests that IgM immune complexes may be involved in the formation of caseous necrosis.