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糖尿病视网膜病变是糖尿病的主要并发症,也是中老年人失明的重要原因之一。血管新生被普遍认为是糖尿病视网膜病变的治疗靶点。综述可用于治疗糖尿病视网膜病变的抗血管新生药物,包括抗血管内皮细胞生长因子药物、皮质类固醇激素、蛋白激酶C-β抑制剂和色素上皮衍生因子等的研究进展,为该类药物的深入开发和临床应用提供思路。
Diabetic retinopathy is a major complication of diabetes and is also one of the major causes of blindness in the elderly. Angiogenesis is widely recognized as a therapeutic target for diabetic retinopathy. This review summarizes the research progress of anti-angiogenic agents, including anti-vascular endothelial growth factor, corticosteroid, protein kinase C-β inhibitor and pigment epithelium-derived factor, which can be used to treat diabetic retinopathy. And clinical application of ideas.