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为探索血浆内皮素－1（ET1）与糖尿病视网膜病变发生发展的关系，我们用放射免疫法对确诊的糖尿病视网膜病变患者44例、糖尿病无视网膜病变患者12例以及正常对照组30例血浆ET1水平进行了检测及分析。结果糖尿病患者血浆ET1浓度显著高于正常对照组，而糖尿病视网膜病变组又明显高于糖尿病无视网膜病变组，其中以增殖型糖尿病视网膜病变组血浆ET1浓度最高。表明糖尿病机网膜病变的发生发展与血浆中ET1浓度的增加有关。
To explore the relationship between ET-1 and the development of diabetic retinopathy, we used radioimmunoassay to determine the level of plasma endothelin (ET1) in 44 patients with diabetic retinopathy, 12 patients without diabetic retinopathy and 30 normal controls Conducted testing and analysis. Results The concentration of plasma ET1 in diabetic patients was significantly higher than that in normal controls, while the diabetic retinopathy group was significantly higher than that in diabetic patients without retinopathy. The concentration of ET1 in proliferative diabetic retinopathy group was the highest. This suggests that the development of diabetic retinopathy is associated with an increase in ET1 concentration in plasma.