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原发性纵隔(胸腺)大B细胞淋巴瘤(PMBL)和弥漫性大B细胞淋巴瘤(DLBCL)是两种临床特点和分子遗传学特征不同的肿瘤,仅通过组织病理学和免疫表型分析难以区分。程序性细胞死亡1配体2(PD-L2)是活化巨噬细胞和树突状细胞结合T细胞PD-1分子后产生的抑制免疫应答的细胞表面蛋白。扩增伴或不伴染色体9p24.1易位,区域中包含了PDCD1LG2编码的PD-L2。该区域的扩增和(或)易位
Primary mediastinal (thymus) large B-cell lymphoma (PMBL) and diffuse large B-cell lymphoma (DLBCL) are two tumors of differing clinical and molecular genetic characteristics that are only characterized by histopathology and immunophenotyping Difficult to distinguish. Programmed cell death 1 Ligand 2 (PD-L2) is a cell surface protein that inhibits immune responses after activated macrophages and dendritic cells bind to T-cell PD-1 molecules. Amplification with or without chromosomal 9p24.1 translocation, region contains PDCD1LG2-encoded PD-L2. Amplification and / or translocation in this area