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目的 评价 3 1PMRS在犬顿抑心肌研究中的应用价值。方法 10条健康杂种犬开胸阻断左冠状动脉前降支 2 0min后 ,解除阻断予以再灌注 ,分别在术前、术后 2、4、6、8h ,1、2、3、12d不同时间点进行心肌3 1PMRS的动态检测。结果 正常对照组结果显示 ,心肌组织磷酸肌酸 /β -三磷酸腺苷 (PCr/β -ATP)和无机磷酸盐 /磷酸肌酸 (Pi/PCr)的比值分别是 1.70± 0 .6 1与 0 .2 0± 0 .0 8,pH值为 7.19± 0 .2 0。顿抑心肌再灌注后 2h ,PCr/β -ATP和 pH值下降 (Ρ <0 .0 5 ) ,Pi/PCr比值提高 (Ρ <0 .0 1) ;PCr/β -ATP在再灌注后 4h时接近正常 ,之后无明显差异 ;而Pi/PCr比值上升持续到再灌注后第 3d ,在第 12d恢复至正常水平。pH值在再灌注后 6～ 8h逐渐恢复正常。结论 心肌缺血再灌注后 ,Pi/PCr比值的变化能较早且准确地反映心肌的代谢状态 ,为临床早期诊断顿抑心肌提供了一种无创性连续观测的新方法。
Objective To evaluate the value of 3 1 PMRS in the study of myocardial infarction myocardium. Methods Ten healthy mongrel dogs were subjected to thoracotomy to block the anterior descending branch of left anterior descending coronary artery 20 minutes later, then they were unblocked and reperfused. The differences were observed before and 2, 4, 6, 8h, 1, 2, 3, Time myocardial myocardial 3 1PMRS dynamic detection. Results The results of normal control group showed that the ratios of creatine phosphorylation / β-ATP (Pi / PCr) and PCr / β-ATP were 1.70 ± 0.61 and 0.2 0 ± 0. 0 8, pH value of 7.19 ± 0. After 2h of reperfusion, the ratio of PCr / β-ATP and pH decreased (P <0.05) and the ratio of Pi / PCr increased (P <0.01) Close to normal after no significant difference; and Pi / PCr ratio increased to the first 3 days after reperfusion, returned to normal levels on the 12th day. The pH gradually returned to normal after 6 ~ 8h after reperfusion. Conclusion The changes of Pi / PCr ratio can reflect the metabolic state of myocardium earlier and more accurately after myocardial ischemia / reperfusion, and provide a new noninvasive and continuous method for the early diagnosis of stunned myocardium.