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目的:探讨二甲双胍治疗多囊卵巢综合征的疗效。方法:回顾性分析我院2013年3月~2014年3月收治的PCOS患者56例的临床资料,对其采取二甲双胍治疗,观察治疗前后各项指标、治疗后月经情况及其药物副反应。结果:治疗后BMI、WHR、FINS、LH、T与治疗前比较,显著下降,差异有显著性(p<0.05);治疗后FSG、FSH与治疗前比较下降,差异无显著性(p>0.05);治疗后E2与治疗前比较上升,差异无显著性(p>0.05)。24例继发闭经恢复有排卵月经14例(58.33%);32例月经稀发恢复正常21例(65.63%)。服药期间4例患者出现间断性腹泻,2例患者出现轻微恶心,未处理,均缓解,未影响治疗;无低血糖发生,治疗后肝肾功能未出现损害。结论:二甲双胍治疗PCOS能够迅速改善患者症状,疗效显著,不良反应少,值得临床推广应用。
Objective: To investigate the efficacy of metformin in the treatment of polycystic ovary syndrome. Methods: The clinical data of 56 patients with PCOS who were treated in our hospital from March 2013 to March 2014 were retrospectively analyzed. Metformin was used to treat them. The indexes before and after treatment, the menstruation after treatment and the side effects of the drugs were observed. Results: After treatment, BMI, WHR, FINS, LH and T decreased significantly compared with those before treatment (p <0.05); FSG and FSH decreased after treatment, with no significant difference (p> 0.05 ); After treatment E2 increased compared with before treatment, the difference was not significant (p> 0.05). In 24 cases, 14 cases (58.33%) had ovulatory menstruation recovered after amenorrhea and 21 cases (65.63%) had normal menstrual hair loss. 4 patients during medication intermittent diarrhea, 2 patients with mild nausea, untreated, were relieved, did not affect the treatment; no hypoglycemia, liver and kidney function did not appear after treatment damage. Conclusion: Metformin in the treatment of PCOS can rapidly improve the symptoms of patients with significant curative effects and few adverse reactions, which is worthy of clinical application.