人类精浆含有补体抑制因子,有较强的抗补体活性。其中的补体溶解抑制因子SP-40/40已得到重组制品,小鼠体内的硫化糖蛋白(SGP-2)和公羊体内的群集素(clusterin)与SP-40/40是不同种系的同源体,具有相似的特性和功能,因而三者统一命名为群集素。本文对这种具有抑制补体活性的群集素的近年研究进展加以介绍。 Human seminal plasma contains complement inhibitory factor, a strong anti-complement activity. Among them, the recombinant lysis inhibitor SP-40/40 has been obtained as a recombinant product. Sulfated glycoprotein (SGP-2) in mice and clusterin in ram are different from SP-40/40 Source body, with similar characteristics and functions, so the three unified named as a cluster element. This article describes the progress of recent studies on this kind of clusterin with its inhibitory activity.