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目的探讨肺硬化性血管瘤的病理学组织特征及临床特点。方法收集我院11例患者的肺硬化性血管瘤组织进行病理学检测及免疫组织化学研究。结果 11例患者中肿瘤均属于单发,呈圆形或卵圆形,无包膜,颜色呈灰色或黄褐色,切面实性,质地硬韧,主要由乳头状结构、实性结构、硬化性结构及出血区构成。免疫组织化学检测显示立方状表面细胞及圆形细胞TTF-1及EMA表达阳性,立方状表面细胞广谱CK表达阳性,圆形细胞表达阴性。少数患者2种细胞均能够显示SYN表达阳性,1例患者PR表达阳性。结论肺硬化性血管瘤发病率低,一般多发于中青年女性,临床上误诊为肺癌的几率较大。因此加强对本病病理学组织特征的认识能够降低误诊率,同时应了解ER、PR的阳性表达与女性发病率较高关系密切。
Objective To investigate the pathological features and clinical features of pulmonary sclerosing hemangiomas. Methods A total of 11 patients with pulmonary sclerosing hemangioma in our hospital were collected for pathological examination and immunohistochemistry. Results The tumors of 11 patients were all single, round or oval, without coating, the color was gray or yellow brown, the cutting plane was solid and the texture was hard and firm. The tumor mainly consisted of papillary structure, solid structure, sclerosis Structure and hemorrhage area. Immunohistochemistry showed that the positive cells were positive for cubic surface cells and round cells, while the positive cells for cuboidal surface cells were positive for CK and negative for round cells. A small number of patients with both kinds of cells can show SYN positive, 1 patients with PR expression was positive. Conclusions The incidence of pulmonary sclerosing hemangioma is low, and it is more common in young and middle-aged women. The probability of misdiagnosis as lung cancer is higher in clinic. Therefore, strengthening the understanding of the pathological features of this disease can reduce the misdiagnosis rate, and at the same time, it should be understood that the positive expression of ER and PR is closely related to the higher incidence of female.