论文部分内容阅读
目的 了解心房利钠肽 (ANP)Va17Met多态性与中国人群缺血性脑卒中之间的关系。方法 我们利用PCR和分子杂交技术对该位点在北京地区缺血性脑卒中患者 (2 94人 )中的分布进行了检测和分析 ,并与非卒中人群 (2 80人 )进行比较。结果 7Met等位基因在病例组和对照组中分布频率分别为 2 5 5 %和 5 36 % ,有统计学差异 ;缺血性脑卒中患者中 7Met携带者(包括ValMet杂合子和MetMet纯合子 )比例明显低于对照组 (5 1%vs10 0 % ) ,同ValVal纯合子相比 ,7Met携带者缺血性中风的比值比为 0 484(95 %可信限 :0 2 5 6～ 0 916 ) ,特异危险性百分比和人群归因危险性百分比分别为 - 5 0 6 2 %和 - 2 5 8%。结论 提示 7Met位点对中国人群缺血性脑卒中发病可能具有保护作用
Objective To understand the relationship between atrial natriuretic peptide (ANP) Va17Met polymorphism and ischemic stroke in Chinese population. Methods We analyzed and analyzed the distribution of this locus in ischemic stroke patients (2 94) in Beijing using PCR and molecular hybridization techniques and compared them to non-stroke patients (280). Results The frequency of 7Met allele was 25.5% and 53.6% respectively in case group and control group, with significant difference. Among 7Met carriers (including ValMet heterozygote and MetMet homozygote) in ischemic stroke patients, (51% vs 100%). Compared with the ValVal homozygotes, the odds ratio of ischemic stroke in 7Met carriers was 0 484 (95% confidence interval: 0 2 5 6 ~ 0 916) , The percentage of specific risk and the percentage of at-risk of at-population were -50 6 2% and -258%, respectively. The results suggest that 7Met may have a protective effect on the ischemic stroke in Chinese population