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急性早幼粒细胞白血病（APL）约占成人急性髓性白血病（AML）的10％，APL的特征为在粒系发育过程中，细胞的分化被阻滞于早幼粒阶段。有研究发现：与其他白血病细胞株相比，NB4细胞（APL的细胞株）抗氧化应激的能力较弱，一些临床上有效治疗APL的药物如AS2O3，可通过诱导氧化应
Acute promyelocytic leukemia (APL) accounts for about 10% of adult acute myeloid leukemia (AML), and APL is characterized by cell differentiation that is arrested in the promyelografts during granulocyte development. Some studies have found that compared with other leukemia cell lines, NB4 cells (APL cell lines) are less able to resist oxidative stress and some clinically effective drugs for treating APL such as AS2O3 can induce oxidative stress