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东方的生药地骨皮是枸杞(Lycium chinense Mill)的根皮,具有清热、强身、降压作用。作者从中提取二个全新环状八肽,命名为枸杞素A(1)(lyciumin A,0.007％)和枸杞素B(2)(lyciumin B,0.01％),它们具有抗肾上腺皮质(ACE)和肾素(renin)的活性,本文对(1)(2)进行了结构鉴定。枸杞素A(1),无定形粉末(〔a〕D+10.1°),经茚三酮,2.4-二硝基苯(DNP)反应,苄基化反应(并对反应产物进行了UW、FAB-MS波谱分析)后,又经水解、1~H和(13)~CNMR、1~H-1~H和(13)~H-(13)CCOSY光谱、NOE谱,分析确定了氨基酸顺序与数目,表明结构中吲哚分子N~1与其他氨基酸—CH—形成分
Oriental medicine is the root skin of Lycium chinense Mill (Lycium chinense Mill) the root bark, with heat, physical, antihypertensive effect. The authors extracted two novel cyclic octapeptides named lyciumin A (0.007%) and lyciumin B (0.01%), which have anti-adrenal cortex (ACE) and Renin (renin) activity, the paper (1) (2) were identified. Lycidine A (1), amorphous powder ([a] D + 10.1 °) was subjected to a benzylation reaction with ninhydrin and 2.4-dinitrobenzene (DNP) -MS spectral analysis), the amino acid sequence and amino acid sequence were determined by hydrolysis, 1 H and 13 C NMR, 1 H-1 H and 13 H-13 CCOSY spectra and NOE spectra, Number, indicating that the structure indole molecule N ~ 1 and other amino acids -CH-shaped components